Postdoctoral fellows with suitable interest and expertise are needed for the following projects:
1. Investigation of the role of halofuginone in the regulation of inflammation and immunity. Halofuginone is a natural produce derived small molecule with potent anti-inflammatory and anti-fibrotic activity in a variety of disease models. We have recently identified the molecular target of halofuginone action, and are investigating the mechanisms by which exerts therapeutic benefits. Projects to define the changes in cellular phenotype and gene expression that underly the therapeutic benefits of halofuginone in models of chronic inflammatory disease are available.
2. Signaling pathways mediating the cellular response to metabolic restriction. We have found that cellular sensing of amino acid availability selectively modulates cell behavior in vitro and in vivo, and that the signals that mediate these effects have implications for metabolic and inflammatory disease, as well as for pathological changes associated with aging. Projects to examine the molecular pathways that underly these signals are available
3. Project ideas consistent with the lab’s general interests are welcomed.